The topic of the instance only really plays a role in Mastodon. With Sharkey and most other Fediverse software, there are much better features for structuring the content you are interested in. In Friendica, for example, via the channels and in Sharkey, Misskey and its other forks with the Antennas / News Picker
I don’t know, I have very good experiences with the Antennas. It (almost always) delivers the expected content. Do you perhaps have a keyword that is also (part of) an instance name?
Then it would have to be added as an excluded word.